Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx
SP-A and SP-D function has been related to innate immunity of the lung based on their binding to sugar residues at pathogen surfaces. Here, we demonstrated that these proteins bind to glycosaminoglycans present at typical cell surfaces like the alveolar epithelial glycocalyx.
