Open Access

44 posts

We believe in the importance of sharing the new knowledge that research creates along our work. Therefore we promote the access of everyone to our publications by making them open access. Here you can find the complete list of our open access publications

Enzymatic modulation of the pulmonary glycocalyx enhances susceptibility to Streptococcus pneumoniae

Cengiz Goekeri, Kerstin A.K. Linke, Karen Hoffmann, Elena Lopez-Rodriguez, Vladimir Gluhovic, Anne Voß, Sandra Kunder, Andreas Zappe, Sara Timm, Alina Nettesheim, Sebastian M.K. Schickinger, Christian M. Zobel, Kevin Pagel, Achim D Gruber, Matthias Ochs, Martin Witzenrath, Geraldine Nouailles. Am J Res Cell Mol Biol 2024: in press To

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Comparative electron microscopic visualization of the lung alveolar epithelial glycocalyx with different staining and labeling methods

Vladimir Gluhovic, Sara Timm, Wolfgang M. Kuebler, Elena Lopez-Rodriguez, Matthias Ochs. Journal of Anatomy, 2024: 00, 1–12 To access the full article, click here: The alveolar surface of the lung is lined by an epithelium consisting of type I (AECI) and type II alveolar epithelial cells (AECII). This epithelium

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Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx

SP-A and SP-D function has been related to innate immunity of the lung based on their binding to sugar residues at pathogen surfaces. Here, we demonstrated that these proteins bind to glycosaminoglycans present at typical cell surfaces like the alveolar epithelial glycocalyx.

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Cholesterol-mediated inflammation activation in alveolar macrophages

Registered Report in principle acceptance

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The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment

The present study provides quantitative data on the differential glycocalyx distribution on AEI and AEII based on cThO2 and demonstrates alveolar glycocalyx shedding in response to HEP or PLY resulting in a structural reduction in both glycosaminoglycan height and density.

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Ten simple rules for implementing open and reproducible research practices after attending a training course

We describe ten simple rules to guide participants of relevant training courses in implementing robust research practices in their own projects, once they return to their research group.

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Resting time after phorbol 12-myristate 13-acetate in THP-1 derived macrophages provides a non-biased model for the study of NLRP3 inflammasome

Differentiation of THP-1 with 5ng/ml PMA followed by 24h resting period provides a model that morphologically and molecularly resembles macrophages.

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Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Hoffmann, K., Obermayer, B., Hönzke, K., Fatykhova, D., Demir, Z., Löwa, A., Alves, L.G.T., Wyler, E., Lopez-Rodriguez, E., Mieth, M., Baumgardt, M., Hoppe, J., Firsching, T.C., Tönnies, M., Bauer, T.T., Eggeling, S., Tran, H.L., Schneider, P., Neudecker, J., Rückert, J.C., Gruber, A.D., Ochs,

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The ultrastructural heterogeneity of lung surfactant revealed by serial section electron tomography: insights into the 3-D architecture of human tubular myelin

Lettau, M., Timm, S., Dittmayer, C., Lopez-Rodriguez, E., Ochs, M.: Am J Physiol-Lung C. 2022;322(6):L873-81. To access the full article, click here: Weibel’s hypothetical three-dimensional (3-D) model in 1966 provided first ultrastructural details into tubular myelin (TM), a unique, complex surfactant subtype found in the hypophase

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