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Our project
In this project, we investigate the role of cholesterol and lipid metabolism in the development of lung fibrosis. We want to know if accumulation of cholesterol in the lung initiate an inflammatory response, such as activation of the NLRP3 inflammasome. Interestingly, we have observed impaired cholesterol metabolism in the absence of SP-C and we are looking for its relation to familial forms of lung fibrosis, where patients present mutations on the SP-C gene. With this knowledge we aim to develop new therapies for this disease.
Our team
We are Mariza Vaso, PhD student (left), Elena Lopez-Rodriguez, project leader (middle) and Sonia Giambelluca, post-doctoral researcher (right).
Our project funding
Project-related publications
for more information: https://www.ekfs.de/en/scientific-funding/currently-funded-projects/immunometabolic-reprogramming-target-cholesterol
